A building exploded and collapsed in East Harlem this morning, injuring at least 11 people and killing two.

The FDNY said 33 units and 106 firefighters are en route to the building, which is at 116th and Park. Metro-North has suspended all service out of Grand Central.

UPDATE 12:26 pm: At a press conference, Mayor Bill de Blasio said the explosion was caused by a gas leak, and that residents "had no warning in advance." He confirmed that there have been two deaths, and that several people remain missing. 250 firefighters are still battling the 5-alarm fire, and Con Ed is working to shut down all gas lines in the area.