HBO wants you to add another must-see film to your list: The Immortal Life of Henrietta Lacks. The film, which is produced by and stars media mogul Oprah Winfrey, is based on the best selling book about a Black women whose cells were taken without her consent and used to develop a slew medical breakthroughs, like the polio vaccine, gene mapping, cloning, and in vitro fertilization.

The film adaptation of Rebecca Skloot’s nonfiction tome will be told from her daughter Deborah’s perspective, and will chronicle Deborah’s “search to learn about the mother she never knew and understand how the unauthorized harvesting of Lacks’ cancerous cells in 1951 led to unprecedented medical breakthroughs, changing countless lives and the face of medicine forever.”

The former daytime talkshow host bought the rights to the film adaption of Skloot’s book in 2010, but the project languished for years. Now, it’s hitting TV screens in April.

In addition to Winfrey, who’ll play Deborah Lacks, The Immortal Life of Henrietta Lacks stars Leslie Uggams, Courtney B. Vance, Rocky Carroll,Ruben Santiago-Hudson, Rose Byrne, Reg E. Cathey, Reed Birney, John Douglas Thompson, Renee Elise Goldsberry, Adriane Lenox, Kyanna Simone Simpson and Roger Robinson.

Check out the full trailer below: 

The Immortal Life of Henrietta Lacks premieres on HBO on April 22 at 8pm. Will you be watching?